Abstract
The cation-independent mannose 6-phosphate receptor (CI-M6PR) is essential for the endocytosis of proteins bearing the mannose 6-phosphate (M6P) recognition marker. This study described the synthesis of M6P and M6S analogs presenting greater affinity for CI-M6PR than their natural compounds. Moreover, the finding of their lack of cytotoxicity for human cells and of their increased stability in human serum supports the high potential of these isosteric derivatives in therapies requiring CI-M6PR targeting.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Binding, Competitive*
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Glycoproteins / metabolism
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Humans
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Lysosomes / enzymology
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Mannosephosphates / blood*
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Mannosephosphates / chemistry
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Molecular Structure
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Neoplasms / drug therapy
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Organophosphonates / blood
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Organophosphonates / chemical synthesis*
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Organophosphonates / chemistry
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Receptor, IGF Type 2 / blood*
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Receptors, Cytoplasmic and Nuclear / drug effects*
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Structure-Activity Relationship
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Sulfonic Acids / blood
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Sulfonic Acids / chemical synthesis*
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Sulfonic Acids / chemistry
Substances
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Glycoproteins
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Mannosephosphates
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Organophosphonates
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Receptor, IGF Type 2
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Receptors, Cytoplasmic and Nuclear
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Sulfonic Acids
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cation-dependent mannose-6-phosphate receptor
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mannose-6-phosphate